Cholinesterase's activities of infected mice by Brucella ovis

Abstract The role of cholinesterase in inflammatory reactions has been described in several infectious diseases. However, in Brucella spp. this has not yet been studied. Therefore, the objective of this study was to evaluate whether experimental infection by Brucella ovis alters the cholinergic activity in pro- or anti-inflammatory responses to the disease. For the study 48 mice were used, 24 infected by B. ovis and 24 non-infected. We collected samples of whole blood on days 7, 15, 30 and 60 post-infection (PI) by B. ovis . Acetylcholinesterase (AChE) activity in the blood increased on days 15 and 60 PI ( P P P B. ovis infection leads to oxidative stress, and consequently to cellular damage.