Lipid metabolism proteins, combinations of lipid metabolism proteins and applications thereof

A polynucleotide comprising a nucleic acid sequence selected from the group consisting of: (a) a nucleic acid sequence as shown in SEQ ID NOS: 436, 438, 440, 442 or 444; (b) a nucleic acid sequence encoding a polypeptide having an amino acid sequence as shown in SEQ ID NOs: 437, 439, 441, 443 or 445; (c) a nucleic acid sequence which is at least 70% identical to the nucleic acid sequence of (a) or (b), wherein the nucleic acid sequence encodes a polypeptide having lipoprotein activity, and wherein the polypeptide has at least one of the amino acid sequences shown in any of SEQ ID NOs: 448 or 449; and (d) a nucleic acid sequence which is a fragment of any one of (a) to (c), said fragment encoding a polypeptide or a biologically active portion thereof having lipoprotein activity and wherein said polypeptide has at least one of the amino acid sequences shown in any of SEQ ID NOs: 448 or 449.