Relationship between brain tissue oxygen (PbrO2) and cerebral perfusion pressure (CPP)

Ischemia is the leading cause of secondary brain damage after severe head injury (SHI). Adequacy of cerebral oxygenation can be assessed by monitoring: cerebral perfusion pressure (CPP), the driving pressure of cerebral perfusion; oxygen saturation of jugular bulb (SjO2), the ratio between global cerebral oxygen availability and consumption: partial pressure of brain tissue oxygen (PbrO2), the driving pressure of oxygen diffusion to mitochondria at tissue level [1,2].