Inhibition of nucleic acid synthesis in the regenerating limb of salamanders treated with a dl-methadone or narcotic antagonists

Abstract Intraperitonal injection of single dose of methadone, 2 mg/kg/day, cyclazocine, 1 mg/kg/day, or naltrexone, 10 mg/kg/2 days to Ambystoma mexicanum significantly retarded limb regeneration rates. [H + ]) uridine incorporation into RNA of the regenerating limb in Ambystoma tigrinum was profoundly inhibited ( P P