Abstract 12894: The Relations of Central Hemodynamics and Aortic Stiffness With Cardiac Structure and Function: The Framingham Heart Study

Introduction: Relations of steady and pulsatile components of central hemodynamics and aortic stiffness with cardiac dimensions and function have not been fully elucidated. Methods: We measured mean arterial pressure (MAP, steady component of blood pressure), central pulse pressure (CPP, pulsatile component of central blood pressure), and carotid-femoral pulse wave velocity (CFPWV, a measure of aortic stiffness) by arterial tonometry in 5799 Framingham Heart Study participants (mean age 51 years, 54% women). We related these to echocardiographic left ventricular (LV) dimensions and systolic and diastolic function using multivariable-adjusted partial Pearson correlations. Results: MAP was associated positively with LV wall thickness (r=0.168; p<0.0001) and LV diastolic dimension (r=0.035, p=0.006). Adjusting for MAP, CPP was positively associated with LV wall thickness and LV diastolic dimension (r=0.044 and r=0.080, both p<0.0001). CFPWV was not associated significantly with LV structure (all p≥0.27) in M...