Anticlastogenic potential of pigeonpea (Cajanus cajan (L.) Millsp.) in white mice (Mus musculus L.)
2016
This study investigated the anticlastogenic potential of International Crop Research Institute for Semi-Arid Tropics (ICRISAT)
bred pigeonpea utilizing the micronudeus test using white mice models to determine the number of micronucleated
polychromatic erythrocytes (MPCEs) in treated and non-treated white mice at the Pampanga State Agricultural University
(PSAU), Magalang, Pampanga, Philippines. Furthermore, the study disclose if pigeonpea has detrimental effects on the vital
signs and some vital organs such as lungs, heart, liver, kidney and intestine. Based on the study, pigeonpea ICPL 87051
leaves decoction have anticlastogenic effects. This might be attributed to the presence of flavonoids, tannins and stilbenes in
pigeonpea leaves that has the ability to lower MPCEs in treated and non-treated white mice. In terms of its effects on the vital
signs namely heart rate, respiratory rate and temperature, results showed that pigeonpea did not cause heart palpitation,
tachycardia, hyperpnea and hypothermia. Treatments T+ (Positive control, TCN) and T2 (Pigeonpea leaves extract of 0.5 per
20 kg body weight + TCN) have normal heart, liver, kidney, lungs and intestines.
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