Chromatin proteins specifically interacting with certain DNA sequences. Nuclear factor I

A comprehensive survey of the data on the nuclear factor I (NF-I) published by the end of 1987 is given. Among all the known DNA-binding chromosomal protein factors which are capable of specific interaction with certain nucleotide sequences, NF-I compels a particular attention as the first example of a conservative multifunctional factor being involved in the assembly of nuclease-hypersensitive chromatin structure within regulatory regions of active genes, in the trans-activation of RNA polymerase II transcription, and also in the replication of the adenoviral genome and presumably in the replication of some other DNAs including the cellular one.