High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

Carsten Krieg,Malgorzata Nowicka,Silvia Guglietta,Sabrina Schindler,Felix J. Hartmann,Lukas M. Weber,Reinhard Dummer,Mark D. Robinson,Mitchell P. Levesque,Burkhard Becher

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

2018

Carsten Krieg
Malgorzata Nowicka
Silvia Guglietta
Sabrina Schindler
Felix J. Hartmann
Lukas M. Weber
Reinhard Dummer
Mark D. Robinson
Mitchell P. Levesque
Burkhard Becher

Among many populations of blood cells, high dimensional analysis using mass cytometry reveals classical monocyte frequency as strong predictors of response to PD-1 blockade therapy of melanoma.

Keywords:

Melanoma
Immunology
Blockade
Monocyte
Immunotherapy
Dermatology clinic
Medicine
Single-cell analysis
Mass cytometry
Biomarker (medicine)
high dimensional

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