Continuous L-arginine infusion does not deteriorate the haemodynamic condition in patients with severe sepsis

Septic patients have reduced plasma arginine (ARG) levels, and have been considered ARG deficient. This has resulted in the use of ARG-enriched enteral formulas, which recently raised much concern. These formulas, however, also contain other components besides ARG. ARG is the precursor for nitric oxide, a known vasodilator. Since little is known about the haemodynamic effects of continuous i.v. ARG supplementation as a single component in sepsis, we aimed to study dose-response effects of ARG in severe septic patients.