Dose-dependent hemodynamic effects of propofol induction following brotizolam premedication in hypertensive patients taking angiotensin-converting

Study Objective: To determine a propofol dose that minimizes hemodynamic changes on induction of anesthesia in patients chronically taking angiotensin-converting enzyme inhibitors (ACEIs). Design: Prospective, randomized trial. Setting: Operating room of a university-affiliated general hospital. Patients: 88 ASA physical status II and II hypertensive patients chronically taking ACEIs, scheduled for elective abdominal surgery with general anesthesia. Interventions: Patients were premedicated with brotizolam and anesthesia was induced with propofol, fentanyl, and rocuronium; anesthesia was then maintained with isoflurane. Patients were randomly assigned to undergo anesthetic induction with propofol in doses of 1.3, 1.6, 2.0, or 2.3 mg/kg.