Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Terance Hart,Alba T. Macias,K Benwell,Teresa Brooks,Jalanie D'Alessandro,Pawel Dokurno,Geraint L. Francis,Ben Gibbons,Timothy Haymes,Guy A. Kennett,Sean Lightowler,Howard L. Mansell,Natalia Matassova,Anil Misra,Anthony Padfield,Rachel Parsons,Robert M. Pratt,Alan Robertson,Steven Walls,Melanie Wong,Stephen D. Roughley

Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

2009

We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.

Keywords:

Enzyme
Amidase
Ether
Urea
Binding site
Organic chemistry
Azetidine
Fatty acid amide hydrolase
Enzyme inhibitor
Biochemistry
Chemistry
Chirality (chemistry)
Stereochemistry
Selectivity
Stereoisomerism

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