The level of thymic stromal lymphopoietin and its gene polymorphism are associated with rheumatoid arthritis

Abstract Objective To study the correlation between TSLP gene SNPs and RA in a Han Chinese population. Methods The genotypes of TSLP genes rs11466749, rs11466750 and rs10073816 among 197 RA patients and 197 controls were analysed by direct sequencing. ELISA was used to detect the plasma TSLP level. Logistic regression analysis was also conducted to identify risk factors for RA. Results The rs11466749 locus GG genotype (OR=5.30, 95% CI: 1.76-15.95, P Conclusion Plasma TSLP levels are a potential molecular marker of RA. SNPs at rs11466749, rs11466750 and rs10073816 of the TSLP gene are related to the susceptibility of the Han Chinese population to RA.