Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes
2010
The aim of this study was to determine their frequency
distribution among 155 Israeli athletes (endurance athletes
and sprinters) and 240 healthy controls. Results showed
that there was a significant difference in PPARGC1A
Ser482Gly polymorphism genotype frequencies between
endurance athletes and sprinters (P50.005) as well as
between endurance athletes and controls (P50.0003).
However, the sprinters’ genotype and allele frequencies
were similar to that of the control group. A significantly
lower proportion of PPARGC1A Ser482 allele (0.25) was
noted for the endurance athletes compared with controls
(0.43, P50.0001). Endurance athletes showed a trend of a
higher yet a not significant proportion of the PPAR alpha GG
genotype compared with sprinters (P50.051). As we compared
between the subgroups of top-level endurance athletes
and top-level sprinters, as well as between those of top-level
and national-level endurance athletes, we reached more
prominent results. In conclusion, our data indicate that a
lower frequency of the Ser482 allele and possibly a higher
frequency of the GG genotype are associated with increased
endurance performance ability.
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