Polyenzymatic therapy in prevention of adhesive processes in the abdominal cavity in children

The clinical investigation included 48 patients with acute adhesive intestinal obstruction resulting from appendectomy and an analysis of the cytokine status in 34 children with acute phlegmonous appendicitis. The patients were divided into two groups: a "polyenzyme" group and a "monoenzyme" group (Hyaluronidase). In the "polyenzyme" group the children were given the preparation Wobenzym in addition to the complex therapy, in the "monoenzyme" group--electrophoresis of Hyaluronidase. In the "monoenzyme" group there were 2 cases of intestinal obstruction. The patients from the "polyenzyme" group had no postoperative complications. Wobenzym was shown to reduce (p < 0.05) the level of pro-inflammatory cytokines (IL-2, IL-6, TNF-alpha) and to increase the level of anti-inflammatory cytokine (IL-4). Using the polyenzyme preparations after abdominal operations in children was found to promote the reduction of intra-abdominal adhesion and inflammatory processes.