원저 : 백서에서의 문신육아종 발생에 관한 실험적 연구

Decorative tattooing has become popular among Korean women, done by many beauticians offering this service. This has resulted in various serious complications including cutaneous granulomas. We tried to produce granulomatous reaction in rats following the injection of eyebrow tattoo pigment. Thiry rats were divided into 3 groups and were injected in tradermally with following materials:tattoo pigment, tattoo pigment and Freund complete adjuvant, and Freund complete adjuvant, respectively. Using an inductively coupled plasma(ICP) spectrometry, quantitative elemental analysis of the original sample of the tattoo dye was done. The results were as follows : 1. In tattoo pigment injected group, foreign body granulomas we`e observed in 7 of 10 rats at one month, which consisted of macrophages, mononuclear cells and foreign body giant cells around tattoo pigment. Little difference was seen in the granulomas between one and two months. In the remaining 3 rats, macrophages that had ingested tattoo pigment and mononuclear inflammatory cells were diffusely scattered in the dermis. 2. In the tattoo pigment and Freund complete adjuvant injected group, all 10 showed foreign body granulomas at one month. Little difference was seen in the granulomas between one and two months. 3. In Freund complete adjuvant injected control group, macrophages and mononuclear inflammatory cells were present in the dermis, but well formed granulomas were not present. 4. By ICP spectrometry, cobalt(11280ppm), calcium(1101ppm), chromium(238ppm), lead(441.6ppm), aluminum(56.52ppm), sodium(456.8ppm), potassium(457.6ppm), magnesium(142.28ppm), phosphorus(25.95ppm), nickel(11.85ppm), copper(1.37ppm) and titanium(0.34ppm) were detected from the tattoo pigment.