Generation and Utility of Tertiary α-Aminoorganolithium Reagents
2004
A general approach to tertiary α-aminoorganolithium reagents by reductive lithiation of α-aminonitriles has been developed. This class of organolithium nucleophiles reacts efficiently with carbonyl electrophiles or in intramolecular cyclizations with tethered phosphate leaving groups. Transmetalation can be used to produce α-aminoorganocuprate reagents that react with alkyl halide electrophiles and in 1,4-additions with enones. These methods establish a new approach for the synthesis of quaternary centers adjacent to nitrogen.
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