A Periodontal Inflammatory Load Indicator in The Relationship between Systemic Disease-Periodontal Disease: PISA

Viral Periodontitis is a chronic inflammatory disease of the supporting tissues surrounding the tooth and is an important cause of tooth loss. Bacteriemia caused by periodontitis is shown as a risk factor for the development of systemic inflammatory response or autoimmune reactions and problems such as diabetes, cardiovascular diseases, negative pregnancy outcomes, chronic obstructive pulmonary disease, rheumatoid arthritis, Alzheimer's. Studies investigating systemic disease-periodontal disease involvement require assessment of inflammatory burden caused by periodontitis. The PISA can be defined as an index of inflammatory load associated with periodontal disease. In this review, it was aimed to evaluate the contribution of the PISA to the systemic state in the studies evaluating the bi-directional relationship between systemic disease and periodontal disease.