Successful pregnancy and birth in a patient with panhypopituitarism caused by craniopharyngioma

Conceptions and uncomplicated pregnancies in patients with panhypopituitarism are rare especially after treatment of craniopharyngioma. We recently experienced a case of a patient with panhypopituitarism who became pregnant by gonadotropin therapy and gave birth to a healthy baby. A 33-year-old woman developed hypogonadotropic hypogonadism and diabetes insipidus because of craniopharyngioma which was surgically removed. Post-operative panhypopituitarism with diabetes insipidus was treated with adequate doses of L-thyroxin, prednisolone, desmopressin, medroxyprogesterone acetate (MPA), conjugated estrogen. To induce ovulation, human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) were administered, and a single intrauterine insemination (IUI) procedure was performed. The patient became pregnant and gave birth to a healthy baby. This case suggests that ovulation induction using gonadotropins and comprehensive hormone replacement therapy can result in the successful pregnancy in patients with panhypopituitarism after treatment of craniopharyngioma.