Research of single herbs in the treatment of Diabetic Peripheral Neuropathy

Although Diabetic peripheral neuropathy seriously affect the patient's quality of life,but its mec-hanism is still not completely clear. Compared to the modern medicine,traditional Chinese medicine treatment of diabetic peripheral neuropathy is more targets and multifaceted. In the research of Single taste of Chinese herbal medicine in treating diabetic peripheral neuropathy has achieved certain progress. According to the tathogenesis of DPN includes three aspects: Metabolic factors(includes Polyol pathway hyperactivity, Inositol reduce, Non-enzymatic Glycati-on end product formation); Vascular disease factors (includes Abnormal fluid rheology, Vascular disorders, Vasoactive factors); The lack of neurotrophic factors, the author reviewed the research progress and problems to be solved in experimental studies and clinical studies of single taste of Chinese herbal and their extracts to treat diabetic peripheral neuropathy.The single taste of Chinese herbal ,which Through the way of Inhibition of the polyol pathway hyperactivity of DPN intervention treatment, include Silymarin, Quercetin,Arctium,Baicalein, Puerarin etc.The way of Breviscapine, Ciwujia injection, Angelica sinensis injection, Ginkgo biloba injection to treat DPN is regulating abnormal blood rheology.Some other single taste of Chinese herbal may stimulate the expression of neurotrophic factors increased to treat DPN.The lack of recognized disease and syndrome animal model, unified diagnostic criteria and unified clinical evaluation are still to be further studied.