The localizing value of ictal SPECT in children with tuberous sclerosis complex and refractory partial epilepsy

Tuberous sclerosis complex is an inherited neurocutaneous disorder which results in mental retardation, behavioral disturbance, and seizures, particularly infantile spasms and partial epilepsy [1] that are highly medically refractory [2-5]. While several of the new antiepileptic drugs offer hope for improved seizure control, [6] excisional surgery is being increasingly considered for refractory patients whose seizures are associated with a single [...]