Study on the Synthesis, Reduction and Reductive Amination of Nitroindan-1-ones. Preparation of N-beta-Hydroxyethyl Derivatives of 6-Aminoindan-1-one and Indan-1,6-diamine

Synthesis of 6-aminoindan-1-one and 7-amino-5,6-dimethoxyindan-1-one by nitration of corresponding indanones, followed by selective palladium catalyzed reduction under mild conditions has been described. Reactions of the amines with oxirane leading to N,N-bis-(β-hydroxyethyl) derivatives were performed. The study of reductive amination of 6-nitroindan-1-one and 5,6-dimethoxy-7-nitroindan-l-one via azines to the corresponding amines as well as synthesis of N,N-bis-(β-hydroxyethyl) derivatives of the amines was also described.