Commentary on: Chick embryo: A preclinical model for understanding Ischemia-reperfusion mechanism.

Research on pertinent, prudently designed, well-characterized, and controlled disease models has been an essential step for fundamental discoveries. The purpose is to understand the disease progression without harming the actual human. In this context, numerous in vitro and in vivo models have been developed and studied to date in ischemia-reperfusion research. However, no in vivo attempts have been made till 2018, till we proposed the recapitulation of ischemiareperfusion injury in a 72 hours developed chick embryo. The present model is useful in understanding the mechanisms of I/R development, drug screening, and stem cell homing.