Derivatives of pyrazolo [1,5-a] pyrimidine and inhibitors of NAD (P) H oxidase containing same

"DERIVATIVES [1,5-a] pyrimidine INHIBITORS AND NAD (P) H oxidase containing same." Disclosed is a compound represented by formula (Ia) (wherein R ~ 1a ~ R ~ 2a ~ and R ~ 3 ~ R ~ 5 ~ are the same as defined in the specification), a prodrug a its pharmaceutically acceptable salt or solvate thereof. The compounds are useful in the prevention or treatment of diseases related to NAD (P) H