Nitrogen heterocyclic compound

PURPOSE: To obtain a new nitrogen heterocyclic compd. effective in treating hypertension, congestive heart failure, etc. CONSTITUTION: The nitrogen heterocyclic compd. is a compd. of formula I [where R 1 is H, alkyl, phenyl, etc.; R 2 is H, alkyl or cycloalkyl; R 3 is R 1 , a halogen, alkoxy, amino, etc.; R 4 is H, amino, OH, alkoxy, alkyl, carboxy, CN, NO 2 , phenyl, etc.; R 5 is H; R 6 is H or alkyl; R 7 is H, alkyl, alkoxy, halogen, CN, etc.; X is phenylene or a direct bond; Rz is H, alkyl, alkanoyl or benzoyl; and Z is 1H-tetrazol-5-yl, COOR 8 (R 8 is H, the residue of a physiologically acceptable alcohol, etc.), etc.] e.g., 2,6-dimethyl-3-iodo-4-[(2'-(1H-tetrazol-5-yl) biphenyl-4-yl)methylamino]pyridine. The compd. of the formula I (where Rz is H or alkyl) is obtd. by alkylating an aminopyridine of formula II with a compd. of formula III (where Hal is a releasable group). COPYRIGHT: (C)1993,JPO