T-Cell Large Granular Lymphocytic Leukemia Involving the Liver and Spleen

T-cell large granular lymphocytic leukemia (T-cell LGLL) is a clonal proliferation of circulating effector memory cytotoxic T-cells. It is often associated with autoimmune disorders. Neutropenia, secondary infection, and splenomegaly are the common clinical features. Anemia and thrombocytopenia can occur. Hepatomegaly and lymph node involvement are seen with an aggressive variant. The majority of T-LGLL appears more common in the elderly, with median age of 65, and has an indolent clinical course. Only 10% of patients died of disease complications, e.g., severe infection. The median survival of T-LGLL is more than 10 years. It was previously proposed that a sustained antigen stimulation leads to an altered apoptotic pathway of LGLs.