SOLUBILITY ENHANCEMENT OF LERCANIDIPINE HYDROCHLORIDE BY COCRYSTALLISATION.
2013
In this study, the significant effect of malonic acid on enhancement of solubility of lercanidipine hydrochloride by simple solvent change process has been demonstrated. Malonic acid and lercanidipine hydrochloride were simultaneously crystallised using water as anti-solvent. The pure drug and different concentrations of malonic acid were characterized in terms of solubility, percentage yield, melting point, crystallinity, thermal behaviour, compatibility studies and surface morphology. The optimised cocrystal formulation exhibited enhancement in aqueous solubility.
KEY WORDS: Lercanidipine Hydrochloride, Cocrystals, Solvent Change Approach, Solubility Enhancement.
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