Asymmetric Reduction of (Z)-α,β-Dehydrotryptophanyl-containing Biological Peptides with Sulfur Functionality. Influence of Substrate on Stereoselectivity
2000
Abstract Two ( Z )-α,β-dehydropentapeptides, Boc-βAla-Δ Z Trp-Met-Asp-Phe-NH 2 1 and Boc-βAlaΔ Z -Trp-NLeu-Asp-Phe-NH 2 2 , have been synthesized by enzymatic α,β-dehydrogenation, and then submitted to rhodium-catalysed asymmetric hydrogenation. The influence of the S-atom on the rate and stereoselectivity of the reduction have been investigated.
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