Serotypes distribution and clinical features of IPD in immunocompromised vs. immunocompetent adults in Spain

Background: Immunocompromise is a main risk factor for Invasive Pneumococcal Disease (IPD). Objectives: To analyse clinical presentations, comorbidities, and outcome of IPD by immunological status and serotypes (Sts) distribution to determine PCV13 coverage. Methods: Prospective surveillance of culture-confirmed IPDs in adults (≥18 years) performed in 7 Spanish hospitals (August 2010-June 2011). Immunocompromise included presence of immunosuppression, HIV infection/AIDS, other immunodeficiencies, cancer or chronic renal disease. Results: 191 cases were included (age 62.2±17.8 years, 58.1% males). Table shows by immunological status, patient characteristics and vaccines coverage. Conclusions: Previous pneumonia is significantly more frequent among immunocompromised patients. PCV13 coverage depends on immunological status, with the highest coverage for immunocompetent patients (64.4%). Facing limitations of the 23-valent polysaccharide (25% of immunocompromised patients had been vaccinated) vaccination with conjugate vaccines could be a better strategy for both immunocompetent and immunocompromised patients.