Click and Pick: Identification of Sialoside Analogues for Siglec‐Based Cell Targeting

The siglec family of sialic-acid binding proteins comprise 15 human and 9 murine members that are primarily expressed on white blood cells which mediate innate and adaptive immune functions.[1] Their restricted expression pattern and activity as endocytic receptors has made them attractive molecular targets for directed therapy of immune-cell mediated diseases.[2] Although anti-siglec antibodies are already in clinical use, nanoparticles decorated with sialoside ligands show promise for targeting siglecs in vivo, providing expanded alternatives for delivery of therapeutic cargo.[3]