New Gastroprokinetic Agent TKS159: 4‐Amino‐5‐chloro‐N‐[(2S,4S)‐1‐ethyl‐2‐hydroxymethyl‐4‐pyrrolidinyl]‐2‐methoxybenzamide
1998
The absolute configuration of the title compound (TKS159, C 15 H 22 C1N 3 O 3 ) has been determined. The bent conformation of the molecule, in which the aromatic and pyrrolidine rings are at nearly 60° to each other, is maintained by intra- and intermolecular hydrogen bonds. A three-dimensional network of hydrogen bonds is formed among the amino, hydroxy and carbonyl groups of neighbouring molecules.
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