NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL Running head title: New activating mutations in NOTCH1

Supported by the WOLF Foundation, the Swim Across America Foundation, the Cancer Research Institute, the Leukemia and Lymphoma Society (grants 1287-08 and 6237-08); NIH grant CA120196, (AF) and the KIKA foundation (LZ). Adolfo Ferrando is a Leukemia and Lymphoma Society Scholar Corresponding Author: Dr. Adolfo A. Ferrando Institute for Cancer Genetics-Columbia University 1130 St Nicholas Avenue, Rm. 505A New York, NY 10032 Phone: (212) 851 4611 Fax: (212) 851 5256 E-mail: af2196@columbia.edu Blood First Edition Paper, prepublished online April 14, 2008; DOI 10.1182/blood-2007-12-130096