Amnesie et autres effets du diazepam dans la premedication et l’induction de l’anesthesie

In this double-blind study, the effects of diazepam (0.15 mg/kg intramuscularly for premedication and 0.3 mg/sec intravenously for induction) on memory were compared to those of standard premedication and induction agents, meperidine (1 mg/kg) and thiopentone (2.5 mg/sec). Forty patients (32 females and 8 males), in physical status I, undergoing minor elective operations, received an auditory stimulus immediately before induction of anaesthesia; stimulus recall as well as subjective side-effects were assessed the following day. The volunteers were randomly assigned to either of two groups, each receiving one of the premedicaments. The two groups were further subdivided into sub-groups corresponding to the induction agents and intubation.