Association of brain network dynamics with plasma biomarkers in subjective memory complainers

Abstract Using a single integrated analysis, we examined the relationship between brain networks and molecular pathways in a cohort of elderly individuals at-risk for Alzheimer’s disease (AD). In 205 subjective memory complainers (124 females, mean age: 75.7±3.4), individual functional connectome was computed for a total of 3,081 functional connections (Set A) and six core plasma biomarkers of AD (Set B) were assessed. Partial least squares correlation analysis identified one dimension of population co-variation between the two sets (p We detected a strong association between network dynamics and core pathophysiological blood biomarkers. Innovative composite biomarkers, such as the bio-neural mode, are promising to provide outcomes and better inform drug development and clinical practice for neurodegenerative diseases.