Renal status in adult volunteers in central Italy: results from Family Abbott Renal Disease Monitoring Project (FARM) study.

Background: Chronic kidney disease (CKD) is a major worldwide problem. A lack of CKD awareness and knowledge of associated risk factors may delay diagnosis and treatment. The purpose of this epidemiological study was to assess the presence and awareness of CKD, in addition to evaluating associated clinical characteristics. Methods: This cross-sectional observational study included 573 healthy volunteers (aged 21-62 years) based in central Italy. All participants underwent a nephrological visit, providing data on medical history, anamnesis and CKD awareness. Blood and urine samples were also collected. Results: Estimated glomerular filtration rate (eGFR) calculated by the abbreviated Modification of Diet in Renal Disease (MDRD) study formula revealed that 55% of participants had an eGFR of <90 ml/min per 1.73 m2 compared with 24.6% by the Cockcroft-Gault formula (C-G; p<0.0001). Approximately 45% of participants showed an awareness of CKD, these subjects also having a significantly lower Framingham score (p<0.046). Approximately half of participants (51%) had insufficient levels (<30 ng/mL) of serum 25-hydroxyvitamin D (25(OH)D), with a higher proportion observed in female (58.3%) than male participants (45.6%, p=0.0016). Levels of 25(OH)D were negatively correlated with eGFR, measured by either MDRD or C-G (r=−0.12, p=0.0039 and r=−0.09, p=0.029 respectively). 1 Department of Nephrology and Dialysis, S. Giovanni Evangelista Hospital, Tivoli Rome 2 Medical Department, Abbott S.r.l., Campoverde (LT), Rome Italy 3 Primula Multimedia S.r.l., Pisa Italy Medical Department, Abbott S.r.l., Campoverde (LT), Rome Italy Antonio Gorini 1, Anna Maria Costanzo 2, Colin Gerard Egan 3, Umberto di Luzio Paparatti 2 Renal status in adult volunteers in central Italy: results from Family Abbott Renal Disease Monitoring Project (FARM) study ORIGINAL ARTICLE DOI:10.5301/jn.5000027