Deceased Donor Predictors for Pediatric Liver Allograft Utilization

2020 
Abstract Background The number of pediatric deceased organ donors has recently declined, and the nonutilization of pediatric liver allografts has limited the development of liver transplantation. We determined the utilization rate of pediatric livers and identified risk factors for graft discard. Methods We used data from the Scientific Registry of Transplant Recipients database from January 1, 2000, to December 31, 2012. The trends of pediatric liver donors and utilization rates were analyzed. Donor risk factors that impacted the graft use of pediatric livers were measured. Logistic regression modelling was performed to evaluate graft utilization and risk factors. Results A total of 11,934 eligible pediatric liver donors were identified during this period. A total of 1191 authorized liver grafts did not recover or recovered without transplantation. Factors including pediatric donors >1 year of age (odds ratio [OR] = 2.956, 95% confidence interval [CI] 2.494-3.503 , P  95% CI 1.903-2.642 , P  95% CI 5.899-9.623 , P  95% CI 1.021-20.625 , P = .047), anti-hepatitis C virus positivity (OR = 4.691, 95% CI 1.352-16.280 , P = .015), total bilirubin >1 mg/dL (OR = 1.743, 95% CI 1.469-2.068 , P  21 mg/dL (OR = 1.941, 95% CI 1.546-2.436 , P  95% CI 0.581-0.806 , P  95% CI 0.634-0.874 , P  Conclusions The pediatric liver allograft utilization rate and risk factors for nonutilization of grafts were determined.
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