Imidazo [4,5-b] pyridin-2-one and analogues thereof as therapeutic compounds against cancer

A compound selected from compounds of the following formula, and pharmaceutically acceptable salts and solvates thereof compound: wherein: J is independently -NRN1-; RN1 is independently -H or -Me; RN2 is independently -H or -Me; Y is independently CH> =; Q is independently -O-; each RP1, RP2, RP5 and RP4 is independently -H, -Me, -CF3, -F or -Cl; the group AL- is independently A-NH-C (> = O) -NH-, AC (> = O) -NH- or AN HC (> = O) -; A is independently phenyl or pyrazolyl, and is independently unsubstituted or substituted with one or more groups selected from: - (C> = O) NH2, - (C> = O) NMe2, - (C> = O) NEt2, - (C> = O) N (iPr) 2, - (C> = O) N (CH2CH2OH) 2, - (C> = O) -morpholino, - (C> = O) NHPh, - (C> = O ) NHCH2Ph, -F, -Cl, -Br, -I, -CN, -OH, -OMe, -OEt, -O (iPr), -O (tBu), -OPh, -OCH2Ph, -OCF3, -OCH2CF3 , -OCF2CF2H, -OCH2CH2OH, -OCH2CH2OMe -OCH2CH2OEt, -OCH2CH2NH2, -20 OCH2CH2NMe2, -OCH2CH2N (iPr) 2, -OCH2CH2-morpholino, piperazino--OCH2CH2, -OCH2CH2-pyrrolidino, -OPh-me, -OPh-OH , -OPh-OMe, -OPh-F, -OPh-Cl, -OPh-Br, -OPh-I, -NH2, -NHMe, -NHEt, -NH (iPr), -NMe2, -NEt2, -N ( iPr) 2, -N (CH2CH2OH) 2, -NHPh, -NHCH 2 Ph, piperidino, piperazino, morpholino, -NH (C> = O) me, -NH (C> = O) Et, -NH (C> = O ) nPr, -NH (C> = O) Ph, -NHC (> = O) CH2Ph, -NMe (C> = O) me, -NMe (C> = O) Et, -NMe (C> = O) Ph, -NMeC (> = O) CH2Ph, -SO2Me, -SO2CF3, -SO2Et, -SO2Ph, -SO2PhMe, -SO2CH2Ph, -SO2NH2, O2NHMe, -SO2NHEt, -SO2NMe2 -SO2NEt2 -SO2-25 morpholino, -SO2NHPh, -SO2NHCH2Ph, -CH2 Ph, -CH2Ph-Me, -CH2Ph-OH, -CH2Ph-F, -CH2Ph-Cl, -Ph, -Ph-Me, -Ph-OH, -Ph-OMe, -Ph-NH2, -Ph-F, -Ph-Cl, -Ph-Br, -Ph-I, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, furanyl, thiophenyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, thiadiazolyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, azepinyl , tetrahydrofuranyl, tetrahydropyranyl, morpholinyl, azetidinyl, -Me, -Et, -nPr, -iPr, -nBu, -iBu, -sBu, -tBu, -nPe, -iPe, tert-Pe, neo-Pe, -cPr, -cHex -CH> = CH2, -CH2-CH> = CH2, -CF3, -CHF2, -CH2F, -CCl3, -CBr3, -30 CH2CH2F, -CH2CHF2, H2CF3, -CH2OH, -CH2OMe, -CH2OEt, -CH2NH2, -CH2NMe2, -CH2CH2OH, -CH2CH2OMe -CH2CH2OEt, -CH2CH2CH2NH2, -CH2CH2NMe2, -CH2CH2-morpholine, -CH2CH2-piperazino, -CH2CH2-pyrrolidino, and> = O; or A is a group selected from pyrazolyl groups of the following formulas: wherein: RPY is independently saturated C 1-7 alkyl; and RN3 are independently phenyl, and is independently unsubstituted or substituted with one or more substituents selected from -F, -Cl, -Br, -I, -OMe, -OCF3, -Me and -CF3.