Clinical evaluation of wound healing capacity of isopod Ceratothoa oestroides oil extract

A very significant health issue worldwide with great impact at personal, professional and social levels, is non-healing ulcers with massive cost in terms of human and material resources. A chronic ulcer is characterized by a persistent inflammation associated with high oxidative stress. A very significant health issue worldwide with great impact at personal, professional and social levels, is non-healing ulcers with massive cost in terms of human and material resources. A chronic ulcer is characterized by a persistent inflammation associated with high oxidative stress. Significant pre-clinical wound healing data of an ointment containing isopod Ceratothoa oestroides (sea lice) oil extract combined with gentamycin, polymyxin B and acetic acid (formula A) leaded to a clinical trial realized to Andreas Syggros Hospital of Cutaneous & Venereal Diseases. The trial was conducted in comparison with a formula containing hyaluronic acid and silver sulfadiazine (formula B). Adult patients with venous or diabetic foot ulcers meeting the required criteria, randomized to receive daily dressing containing either formula A or formula B. Every 2 weeks, patients were clinically evaluated for wound healing progress according to Bates Jensen or PUSH criteria. Measurements of pH, temperature, wound area, oxygen saturation and glucose blood levels were regularly obtained. Formula A demonstrates remarkable wound healing activity.