Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

Joanne E. Bluff,Steven Reynolds,Stephen Metcalf,Tooba Alizadeh,Samira Kazan,Adriana Bucur,Emily Wholey,Becky Bibby,Leigh Williams,Martyn Paley,Gillian M. Tozer

Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

2015

Joanne E. Bluff
Steven Reynolds
Stephen Metcalf
Tooba Alizadeh
Samira Kazan
Adriana Bucur
Emily Wholey
Becky Bibby
Leigh Williams
Martyn Paley
Gillian M. Tozer

Purpose To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised 13C1-pyruvate and magnetic resonance spectroscopy.

Keywords:

Nuclear magnetic resonance spectroscopy
Pyruvic acid
Lactic acid
Radiology
Nuclear magnetic resonance
Reaction rate constant
In vivo
Pyruvate Metabolism
Medicine
Hypoxia (medical)
Fibrosarcoma
tumour oxygenation

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