Conformational transitions and specific heat anomaly in poly(dG-dC) and its methylated analogue.
1992
: The Zimm and Bragg theory of the helix coil transition has been modified to explain order order transitions in polynucleotides, in particular B Z psi(-) coil transitions in poly(dG-dC) and poly(dG-me5dC). Lambda anomalies in specific heat measurements around the transition point have also been explained by a further modification of the same theory. Theoretical results are found to be in good agreement with the experimental data. The nucleation parameter is consistent with the stabilization/destabilization of the ordered states (Z helix) under various environmental conditions, e.g. methylation of cytosine residue at C5 position or change in the cationic concentration of the solvent.
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