Abstract 460: Vascular Smooth Muscle Sirtuin-1 Regulates Tgf-b1 Signaling Pathway in Angiotensin II-induced Aortic Aneurysm and Dissection

Background: Aortic aneurysm and rupture/dissection (AA) are life-threatening diseases associated with hypertension or monogenic syndromes, such as Marfan’s syndrome. Although advances have been mad...