Cu(II) ionic liquid promoted Simple and Economical Synthesis of 1,4-disubstituted-1,2,3-triazoles with Low Catalyst Loading

In this work, we have described a very simple and low metal loading copper-based ionic liquid as solvent and catalyst for regioselective synthesis of 1,4-disubstituted-1,2,3-triazoles. The proposed protocol proved its efficiency by showing excellent tolerance to a large array of electronically diverse substrates without the use of the external base, solvent and ligands. Moreover, from cytotoxicity analysis the catalyst was found to be non-toxic in nature due to extremely low loading of copper metal (0.1 mol %). This work describes a very simple and low metal loading catalytic system for efficient synthesis of 1,4-disubstituted-1,2,3-triazoles. The synthesized copper based ionic liquid acted both as solvent and as catalyst. Cytotoxicity analysis indicates that the catalyst is non-toxic in nature due to extremely low loading of copper metal (0.1 mol%).