Impact of lymphovascular invasion on overall survival in patients with prostate cancer following radical prostatectomy: stage-per stage analysis

ABSTRACT Background The detrimental impact of lymphovascular invasion (LVI) in prostate cancer (PCa) on biochemical recurrence has been described, the impact of LVI on overall survival (OS) remains unclear. The objective of the investigation was to evaluate the impact of LVI on OS in patients with PCa. Methods We examined men with non-metastatic PCa treated with radical prostatectomy between 2010 and 2015 within the National Cancer Database. Only men with documented LVI status were included (n=232,704). Patients were stratified according to final pathological T stage (pT2, pT3a and pT3b). Results Of the 232,704 patients who met inclusion criteria, 17,758 (8%) were found to have LVI on final pathology. Overall, 174,838 (75%), 40,281 (17%) and 17,585 (8%) of patients had pT2, pT3a and pT3b disease, respectively. Median follow-up was 42.7 months (27.1 – 58.7). At 5 years, the OS in LVI vs. non-LVI patients was 94% vs 95% in pT2 (p = 0.0004), 92% vs 95% in pT3a (p Conclusions Our report demonstrates the detrimental impact of LVI on OS in locally advanced prostate cancer (pT3a and higher). This information may prove valuable when risk-stratifying based on final pathology.