ВОЗМОЖНОСТИ ОПТИМИЗАЦИИ ПРЕДОПЕРАЦИОННОЙ ПОЛИХИМИОТЕРАПИИ У БОЛЬНЫХ ИНВАЗИВНЫМ РАКОМ ШЕЙКИ МАТКИ

A comparative evaluation of different methods of neoadjuvant chemotherapy in 67 patients with locally advanced cervical cancer (T1b2-2bN0-1M0 stages) in age from 25 to 48 years was done. Main group included patients, received neoadjuvant chemotherapy in combination with plasmapheresis and non-specific immunotherapy at the first stage of the treatment. The control group included patients who underwent standard neoadjuvant chemotherapy. In both groups the same cytostatics were used. It was established that using of neoadjuvant chemotherapy combined with plasmapheresis and immunotherapy helps to achieve pronounced clinical effect, improve disease-free survival, reduce the frequency and severity of complications of specific treatment and delay the relapse and metastasizing of the disease.