Induced psychosis after withdrawal of varenicline: a case report.

Lopez Arteaga MT, Amo C, Sanchez Morla EM, Sanchez Roman M. Induced psychosis after withdrawal of varenicline: a case report. Objective: Varenicline has been associated with psychiatric side effects, and cases with psychotic symptoms during treatment have been reported, few of them after the withdrawal. We describe a case with no current or previous medical or psychiatric history. Method: A single case report. Results: The patient without previous psychiatric pathology, following the withdrawal of treatment with varenicline, experiences delirium and behavioural disturbances. There was a remission of symptoms after 3 weeks of treatment with risperidone. Conclusion: Discontinuation of treatment with varenicline due to poor tolerance for side effects (nausea and insomnia) could trigger psychotic symptoms in subjects with no personal or family psychiatric history.