The 32.5% difenoconazole-azoxystrobin effervescent tablet optimized by central composite design-response surface method

The aims of the present study are to exam the dispersing agent,disintegrating agent and blowing agent,based on the index of tablet suspension rate and disintegration time.The data is simulated by using multi-nolinear equation to select proper model.The best formulations based on the factors within setting ranges are: WG5(4.75%),TXC(1.50%),PVPP(5.00%),foaming agent(40%).Three times of repeated experiments showed that the average rate of suspension was 86.42%,disintegration time was 159 s,almost equal to the predictions: 86.14% and 160 s.