An Atypical Case of Acute Generalized Exanthematous Pustulosis with Steven Johnson’s Syndrome-Like Features Triggered by a Bacterial Infection

Abstract Acute generalized exanthematous pustulosis (AGEP) is a rare clinical entity characterized by sudden onset of nonfollicular sterile pustules over erythematous skin and accompanied by fever and leukocytosis. Although the most frequent cause of AGEP is systemic drug administration, AGEP cases triggered by infections have occasionally been described. We report a case of a 74 year-old-female who developed an atypical presentation of AGEP, induced by a bacterial infection of her pubic region. To the best of our knowledge, this is the first case of AGEP associated with a Pseudomonas aeruginosa infection. Keywords Acute generalized exanthematous pustulosis (AGEP); Bacterial infection, mucous involvement; Therapy Abbreviations AGEP: Acute Generalized Exanthematous Pustulosis; SCARs: Cutaneous Adverse Reactions to Drugs; DRESS: Drug Reaction with Eosinophilia and Systemic Symptoms; SJS: Stevens-Johnson Syndrome; TEN: Toxic Epidermal Necrolysis