Valproic acid-mediated myocardial protection of acute hemorrhagic rat via the BCL-2 pathway:

BACKGROUNDHemorrhage is a major cause of morbidity and mortality among trauma patients. The pathophysiologic changes following acute severe hemorrhage and tissue hypoxia lead to an imbalance of protein acetylation. Histone deacetylase inhibitors (HDACIs) were reported to restore the acetylation imba