EFFECT OF AMIFOSTINE ON LUNG OXIDATIVE STRESS AFTER CYCLOPHOSPHAMIDE THERAPY

The ability of amifostine to protect healthy rat lung cells from cyclophosphamideinduced injury was evaluated. It was shown that cyclophosphamide decreased the activity of superoxide dismutase, gluthatione reductase and catalase as well as the level of reduced gluthatione, vitamin C and total antioxidant status and increased lipid peroxidation measured as malondialdehyde. Amifostine alone did not change or cause the increase in the antioxidative parameters and decrease in lipid peroxidation. Amifostine with cyclophosphamide only partially prevented changes in lung cells caused by cyclophosphamide.