Variables clínicas y farmacológicas de pacientes nonagenarios hospitalizados por COVID-19

espanolIntroduccion. A pesar del impacto del SARS-CoV-2 en geriatria, disponemos de escasa informacion en pacientes nonagenarios. Nuestro objetivo es describir caracteristicas clinicas, respuesta al tratamiento y factores de riesgo de mortalidad en nonagenarios con COVID-19. Material y metodos. Estudio retrospectivo observacional de pacientes nonagenarios hospitalizados por COVID-19. Se registraron variables sociodemograficas, clinicas y polifarmacia previa, parametros analiticos y tratamiento especifico. Resultados. Se incluyeron 79 pacientes. No se relaciono con mortalidad ninguna de las comorbilidades. La mortalidad fue del 50,6%, siendo mayor en pacientes con dependencia funcional moderada/grave respecto aquellos independientes/ dependientes leves (59,5% vs 40,5%; p=0,015). Los farmacos especificos mas prescritos fueron hidroxicloroquina/cloroquina y azitromicina. Los pacientes fallecidos presentaron mas leucocitos y neutrofilos, y mayor linfopenia. Conclusion. En nuestra cohorte, el estado funcional es el principal factor de riesgo de mortalidad, independientemente de las comorbilidades y el tratamiento recibido. Implementar la valoracion geriatrica integral permitiria individualizar las estrategias terapeuticas en nonagenarios. EnglishIntroduction. Despite the impact of SARS-CoV-2 infection in geriatrics, data on nonagenarian patients is scarce. The aim of this study is to describe the clinical features of COVID19-diagnosed nonagenarians, as well as its clinical evolution and therapeutic response. Material and methods. Retrospective observational study of nonagenarians, admitted for COVID-19. Sociodemographic and clinical variables were registered, including previous polypharmacy. Blood analysis data and COVID-19-specific treatment were registered. Results. A total of 79 patients were included, with 50.6% (40 patients) of mortality. None of the comorbidities registered correlated with mortality, which was significantly higher among patients with moderate/complete functional dependence, compared to those mild-dependents/independents (59.5% vs 40.5%; p=0.015). Most prescribed drugs were hydroxychloroquine/chloroquine and azithromycin. Non-survivors presented higher counts of leukocytes and neutrophils, and higher lymphopenia. Conclusions. Nonagenarians with functional dependence presented higher mortality, irrespective of comorbidities or treatment received. Implementing an integral geriatric evaluation would enhance the implementation of personalized therapeutic strategies for nonagenarians.