High-fat diet during pregnancy acts as a stressor increasing maternal glucocorticoids’ signaling to the fetus and disrupting maternal behavior in a mouse model

Furthermore, positive associations between growth trajectory throughout the first 5 years of life and childhood cognitive ability were observed, in spite of the fact that rapid infancy growth increases the risk to develop obesity, diabetes and hypertension, conditions associated with increased risk to develop cognitive impairment, dementia and Alzheimer’s disease. This lecturewill illustrate the above concepts andwill also show recent data on the early on-set of the relationship between obesity and brain insulin sensitivity and development.